Thermo Fisher Scientific ITFG2 Monoclonal Antibody (OTI 3D8), TrueMAB
ITFG2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 유세포 분석에 적합합니다. HEK293T에서 발현된 전장 인간 ITFG2 단백질로 면역화되었으며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI 3D8 |
| Immunogen | Full length human recombinant protein of human ITFG2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.34 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
As part of the KICSTOR complex, ITFG2 functions in the amino acid-sensing branch of the TORC1 signaling pathway. It recruits the GATOR1 complex to lysosomal membranes, enabling interaction with GATOR2 and RAG GTPases. ITFG2 acts upstream of RAG GTPases and negatively regulates mTORC1 signaling in the absence of amino acids. Without the KICSTOR complex, mTORC1 remains constitutively active and localized to the lysosome. The complex may also play a role in mTORC1 regulation by glucose.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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