Thermo Fisher Scientific Cripto Polyclonal Antibody, HRP
Cripto 단백질을 인식하는 HRP 결합 폴리클로날 항체로, Western blot에 최적화되어 있습니다. 인간과 마우스 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 4℃ 암소 보관, 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 2 µg/mL
- Suggested Positive Control: MDA-MB231 (human breast cancer) lysates
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to an N-terminal portion of the murine Cripto protein sequence (between residues 1–50) |
| Conjugate | HRP |
| Form | Liquid |
| Concentration | 0.94 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | 4°C, store in dark |
| Shipping conditions | Wet ice |
| RRID | AB_11153243 |
Product Specific Information
In Western blot, a band is observed at approximately 18 kDa representing the core form of Cripto1, and at approximately 36 kDa representing the glycosylated or post-translationally modified form.
Target Information
Cripto (TDGF1) is a GPI-anchored cell membrane protein involved in Nodal signaling.
Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells.
TDGF1 is expressed in embryonic stem cells and during early embryo development, and is reactivated in various epithelial cancers in adults.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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