Thermo Fisher Scientific Estrogen Receptor alpha (ER alpha) ER Alpha Recombinant Protein
인간 유래 ER Alpha 재조합 단백질로 핵 수용체 분석에 적합. 비표지, 정제된 액상 형태로 제공되며 고순도(80%) 확보. PolarScreen™ ER Alpha Competitor Assay와 호환 가능. -80°C 보관, 연구용으로만 사용.
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- A15674
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Thermo Fisher Scientific Estrogen Receptor alpha (ER alpha) Recombinant Protein
Applications
- Nuclear Receptor Assay (NR)
Tested Dilution: Assay-dependent
Publications: N/A
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Molecular Weight | 66.4 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | 80% (SDS-PAGE, SimplyBlue™ SafeStain) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | Proprietary buffer |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
For maximum recovery, please spin prior to use.
Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted.
For larger sizes, reduce freeze/thaw cycles by preparing aliquots (≥20 µL). Do not store diluted kinase.
Properly stored at -80°C, the product is guaranteed for 6 months from date of purchase.
ER (Estrogen Receptor) Alpha Recombinant Protein is an insect cell-expressed, full-length, untagged, human nuclear hormone receptor that binds [³H]-estradiol with sub-nM affinity in hydroxylapatite assays and specifically binds to estrogen response element (ERE) sequences.
Features:
- Flexible use in in-house assays or PolarScreen™ ER Alpha Competitor assays
- Ready-to-use, active, purified, and native (untagged)
- Convenient bulk size availability
Manufactured under strict quality parameters. Guaranteed for 6 months after purchase.
For bulk quantities or assay development support, contact: discoverysciences@lifetech.com
Used in:
Protein Form: Recombinant, Full Length
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors.
ER is a ligand-activated transcription factor that, upon estrogen binding, undergoes conformational change enabling dimerization and binding to EREs in DNA.
This interaction regulates gene transcription via coactivator or corepressor recruitment.
Two forms exist: ER alpha (ESR1) and ER beta (ESR2), encoded by separate genes.
At least four ER alpha isoforms are known (66, 53, 47, 35 kDa).
ERs are widely expressed and essential for sexual development, reproduction, and bone function.
They are implicated in diseases such as breast and endometrial cancer, and osteoporosis.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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