Thermo Fisher Scientific MYLK3 Polyclonal Antibody
MYLK3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western blot, ELISA, IP 등 다양한 응용 가능. 고순도 Affinity chromatography 정제, 안정적 액상 형태로 -20°C 보관.
- 카탈로그번호
- MYLK3-301AP
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific MYLK3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 10–60 on human Myosin light chain kinase 3 (MYLK3) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MLCK (MLCK2), also known as MYLK3, is part of the myosin regulatory light chain kinases that facilitate muscle contraction. This Ser/Thr protein kinase phosphorylates myosin light chains, enabling interaction with actin filaments and regulating smooth muscle contraction. It influences vascular permeability, tissue edema formation, and neural functions such as astrocytic process growth and neurotransmitter release. MLCK plays roles in fibroblast apoptosis signaling and is expressed in various adult and fetal tissues. The Telokin isoform binds calmodulin and is widely distributed. MLCK activity is likely down-regulated by phosphorylation. The protein includes one fibronectin type III domain and nine immunoglobulin-like C2-type domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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