Thermo Fisher Scientific DDR2 Recombinant Rabbit Monoclonal Antibody (102)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody shows specificity for Mouse DDR2/CD167b.

Target Information

DDR2 is a member of a subclass of receptor tyrosine kinases (RTKs) with a distinct extracellular region containing a factor VIII-like domain. DDR1 and DDR2 are potently inhibited by Gleevec. DDR2 is required for normal bone development and regulates osteoblast differentiation and chondrocyte maturation through MAP kinase pathways leading to activation of RUNX2. It also regulates extracellular matrix remodeling by upregulating collagenases (MMP1, MMP2, MMP13), facilitating cell migration and tumor invasion. DDR2 promotes fibroblast migration and proliferation, contributing to cutaneous wound healing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.