Thermo Fisher Scientific DNMT3A/DNA Methyltransferase 3 Alpha Monoclonal Antibody (PCRP-DNMT3A-1E2)
DNMT3A 단백질을 인식하는 마우스 모노클로날 항체로, Western blot, IHC(P), Peptide Array에 사용 가능. 인간 시료 반응성, 단백질 A/G 정제, PBS buffer 보존. DNA 메틸화 연구 및 암 관련 메틸화 조절 연구에 적합.
✨AI 추천 연관 상품
AI가 분석한 이 상품과 연관된 추천 상품들을 확인해보세요
연관 상품을 찾고 있습니다...
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-DNMT3A-1E2 |
| Immunogen | Recombinant human full-length DNMT3A protein (1–912 aa, UniProt ID: Q9Y6K1-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA-fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
DNA methylation at cytosine residues is crucial for regulation of gene expression, genomic imprinting, and mammalian development.
Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of genomic DNA is associated with cancer development.
Three families of mammalian DNA methyltransferases have been identified: Dnmt1, Dnmt2, and Dnmt3.
- Dnmt1: Constitutively expressed in proliferating cells; its inactivation causes global demethylation and embryonic lethality.
- Dnmt2: Expressed at low levels in adult tissues; inactivation does not affect DNA methylation.
- Dnmt3 family (Dnmt3a, Dnmt3b): Strongly expressed in embryonic stem (ES) cells; expression decreases during differentiation and is low in adult tissues.
- Mutations in Dnmt3b are associated with ICF syndrome (Immunodeficiency, Centromeric instability, and Facial anomalies).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
🏷️Thermo Fisher Scientific 상품 둘러보기
동일 브랜드의 다른 상품들을 확인해보세요
Thermo Fisher Scientific
Thermo Fisher Scientific DNMT3A/DNA Methyltransferase 3 Alpha Monoclonal Antibody (PCRP-DNMT3A-1E2)
825,100원
Thermo Fisher Scientific
Thermo Fisher Scientific DNMT3A/DNA Methyltransferase 3 Alpha Monoclonal Antibody (PCRP-DNMT3A-1E2)
441,900원
Thermo Fisher Scientific
Thermo Fisher Scientific DNMT3A/DNA Methyltransferase 3 Alpha Monoclonal Antibody (PCRP-DNMT3A-1E2)
825,100원
Thermo Fisher Scientific
Thermo Fisher Scientific Phospho-S6 (Ser235, Ser236) Monoclonal Antibody (cupk43k), APC, eBioscience
212,200원
Thermo Fisher Scientific
Thermo Fisher Scientific Phospho-ZAP70/Syk (Tyr319, Tyr352) Monoclonal Antibody (n3kobu5), APC, eBioscience
530,800원
배송/결제/교환/반품 안내
배송 정보
| 기본 배송비 |
| 교환/반품 배송비 |
|
|---|---|---|---|
| 착불 배송비 |
| ||
| 교환/반품 배송비 |
| ||
결제 및 환불 안내
| 결제수단 |
|
|---|---|
| 취소 |
|
| 반품 |
|
| 환급 |
|
교환 및 반품 접수
| 교환 및 반품 접수 기한 |
|
|---|---|
| 교환 및 반품 접수가 가능한 경우 |
|
| 교환 및 반품 접수가 불가능한 경우 |
|
교환 및 반품 신청
| 교환 절차 |
|
|---|---|
| 반품 절차 |
|