Thermo Fisher Scientific ERAB Polyclonal Antibody
ERAB 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 면역조직화학(IHC)에 적합합니다. 인간 시료 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 알츠하이머 관련 연구 및 미토콘드리아 단백질 분석에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–5 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–116 of human ERAB protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: U251 cells, Alzheimer’s brain
- Cellular location: Mitochondrion
Target Information
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily.
The gene product is a mitochondrial protein that catalyzes the oxidation of fatty acids, alcohols, and steroids.
It has been implicated in the development of Alzheimer’s disease, and mutations in the gene cause 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD).
Several alternatively spliced transcript variants have been identified, with two full-length variants determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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