Thermo Fisher Scientific JMJD1C Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human JMJD1C. Recombinant protein control fragment (Product #RP-93608). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:JMJD1C,uniProtId:Q15652-1,ncbiNodeId:9606,antigenRange:539-648,antigenLength:2540,antigenImageFileName:PA5-63258_JMJD1C_Q15652-1_Rabbit.svg,antigenImageFileNamePDP:PA5-63258_JMJD1C_Q15652-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642853

Product Specific Information

Immunogen sequence: PNVSDSKHSI ANAKFLETAK KDSDQSWVSD VVKVDLTQSS VTNASSGNDH LNMEKEKYVS YISPLSAVSV MEDKLHKRSP PPETIKSKLN TSVDTHKIKS SPSPEVVKPK

Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 77%.

Target Information

The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.