Thermo Fisher Scientific JMJD1C Polyclonal Antibody
Thermo Fisher Scientific의 JMJD1C Polyclonal Antibody는 인간 JMJD1C 단백질을 인식하는 토끼 유래 IgG 항체입니다. IHC(P)와 ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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- PA563258
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human JMJD1C. Recombinant protein control fragment (Product #RP-93608). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642853 |
Product Specific Information
Immunogen sequence:
PNVSDSKHSI ANAKFLETAK KDSDQSWVSD VVKVDLTQSS VTNASSGNDH LNMEKEKYVS YISPLSAVSV MEDKLHKRSP PPETIKSKLN TSVDTHKIKS SPSPEVVKPK
Highest antigen sequence identity to the following orthologs:
- Mouse: 79%
- Rat: 77%
Target Information
The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells, pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors.
The JMJD1C gene promoter contains bHLH-, AP-1-, and POU5F1-binding sites. Preferential expression of POU5F1 in ES cells, pancreatic islet, and diffuse-type gastric cancer suggests that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in these tissues. At least three isoforms of JMJD1C are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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