Thermo Fisher Scientific RNASE3 Polyclonal Antibody
Human RNASE3에 특이적인 Rabbit Polyclonal Antibody로 Western Blot 및 Immunohistochemistry에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태이며, PBS/glycerol buffer에 보존. ECP 단백질 연구 및 염증 관련 바이오마커 분석에 활용 가능.
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Thermo Fisher Scientific RNASE3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RNASE3. Recombinant protein control fragment (Product #RP-95687). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646606 |
Product Specific Information
- Immunogen sequence:
CGNQSIRCPH NRTLNNCHRS RFRVPLLHCD LINPGAQNIS NCTYADRPGR RFYVV - Highest antigen sequence identity to orthologs:
- Mouse: 38%
- Rat: 45%
Target Information
ECP (Eosinophil Cationic Protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein belonging to the pancreatic ribonuclease family.
ECP localizes to the granule matrix of eosinophils and plays a role in the immune response system. It acts as a cytotoxin, neurotoxin, and helminthotoxin secreted by activated human eosinophils.
ECP exhibits anti-parasitic, antibacterial, and ribonucleolytic activities. It is associated with the Gordon phenomenon, a neurotoxic effect characterized by ataxia, muscular rigidity, paralysis, and tremor.
ECP serves as a marker of eosinophilic inflammation, with elevated levels observed in active asthma and other allergic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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