Thermo Fisher Scientific CD8 Monoclonal Antibody (17D8), FITC
인간 CD8 단백질을 인식하는 Mouse IgG1 단클론 항체로, FITC 형광 표지되어 Flow Cytometry에 적합합니다. 단백질 A/G 정제, PBS 버퍼에 보관되며 4°C 암소 저장 권장. 연구용으로 면역세포 분석 및 CD8+ T 세포 검출에 활용됩니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: Assay-dependent
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 17D8 |
| Immunogen | Human peripheral blood T lymphocytes |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.02 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.2% carrier protein |
| Contains | 0.08% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073377 |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, crucial for signal transduction and T cell differentiation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β), functioning as a co-receptor with TCR for MHC-I molecules.
It is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Upon MHC-I/peptide complex binding, CD8 recruits Lck kinase, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs play key roles in pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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