Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (BGX.24), FITC
인체 Transferrin Receptor(CD71)에 특이적인 단일클론 항체로 FITC 형광 표지되어 있음. Flow Cytometry 분석에 적합하며, 단백질 A/G로 정제된 액상 형태. 4°C 암소 보관, 비동결 조건 필요.
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Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (BGX.24), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution
- Assay-dependent
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BGX.24 |
| Immunogen | Blast cells from pokeweed mitogen-stimulated peripheral blood cells |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage buffer | PBS with 0.2% carrier protein |
| Contains | 0.08% sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073340 |
Additional Formats
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome, and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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