Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (BGX.24), PE
인간 Transferrin Receptor(CD71)를 인식하는 Mouse IgG1 단클론 항체. PE 형광표지로 유세포분석(Flow Cytometry)에 적합. 565/576 nm 파장에서 여기/방출. PBS 기반 완충액에 0.08% sodium azide 포함, 4°C 보관.
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Applications
- Flow Cytometry (Flow): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BGX.24 |
| Immunogen | Blast cells from pokeweed mitogen-stimulated peripheral blood cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | PBS with 0.2% carrier protein |
| Contains | 0.08% sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073343 |
Additional Formats
- Unconjugated: MA1-12156
- FITC: MA1-12157
- Custom conjugation available upon request
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome, and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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