Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (BGX.24)
인간 Transferrin Receptor(CD71)을 인식하는 Mouse Monoclonal Antibody (Clone BGX.24). Flow Cytometry 및 Inhibition Assay에 사용 가능. Unconjugated 형으로 제공되며, FITC 및 PE 형식도 선택 가능. Protein A/G 정제, PBS buffer에 0.08% sodium azide 포함, -20°C 보관.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Reference available (1 publication)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BGX.24 |
| Immunogen | Blast cells from pokeweed mitogen-stimulated peripheral blood cells |
| Target Family | Transferrin Receptor (CD71) |
| UniProt ID | P02786-1 |
| Antigen Range | 1–760 |
| Antigen Length | 760 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073348 |
Additional Formats
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from conditions such as rheumatoid arthritis, pregnancy, irritable bowel syndrome, and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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