Thermo Fisher Scientific CLIP1 Polyclonal Antibody
CLIP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도의 Affinity Chromatography 정제 항체입니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1228–1427 of human CLIP1 (NP_002947.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.38 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805019 |
Product Specific Information
Immunogen sequence:
SALLTEKDAE LEKLRNEVTV LRGENASAKS LHSVVQTLES DKVKLELKVK NLELQLKENK RQLSSSSGNT DTQADEDERA QESQIDFLNS VIVDLQRKNQ DLKMKVEMMS EAALNGNGDD LNNYDSDDQE KQSKKKPRLF CDICDCFDLH DTEDCPTQAQ MSEDPPHSTH HGSRGEERPY CEICEMFGHW ATNCNDDETF
Positive Samples: U-87MG, Mouse heart
Cellular Location: Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle membrane, Peripheral membrane protein, cytoskeleton, ruffle
Target Information
CLIP170 was initially identified as a new type of intermediate filament-associated protein highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin’s disease. It localizes at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 interacts with LIS1 to regulate dynein/dynactin binding to microtubules and may influence lamellipodia formation and cell invasion in invasive breast cancer cells through regulation of kinesin and IQGAP1 complex dynamics. At least two isoforms of CLIP170 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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