Thermo Fisher Scientific CLIP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1228-1427 of human CLIP1 (NP_0029471) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CLIP1,uniProtId:P30622-3,ncbiNodeId:9606,antigenRange:1228-1427,antigenLength:1438,antigenImageFileName:PA5-88590_CLIP1_P30622-3_Rabbit.svg,antigenImageFileNamePDP:PA5-88590_CLIP1_P30622-3_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.38 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805019

Product Specific Information

Immunogen sequence: SALLTEKDAE LEKLRNEVTV LRGENASAKS LHSVVQTLES DKVKLELKVK NLELQLKENK RQLSSSSGNT DTQADEDERA QESQIDFLNS VIVDLQRKNQ DLKMKVEMMS EAALNGNGDD LNNYDSDDQE KQSKKKPRLF CDICDCFDLH DTEDCPTQAQ MSEDPPHSTH HGSRGEERPY CEICEMFGHW ATNCNDDETF; Positive Samples: U-87MG, Mouse heart; Cellular Location: Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle membrane, Peripheral membrane protein, cytoskeleton, ruffle

Target Information

CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin`s disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.