Thermo Fisher Scientific AMPK beta 1 (PRKAB1) Monoclonal Antibody (OTI8D5)

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

AMPK beta 1 is a regulatory subunit of the AMP-activated protein kinase (AMPK), a heterotrimeric enzyme complex composed of an alpha catalytic subunit and non-catalytic beta and gamma subunits.
AMPK functions as a key energy sensor in cells, activated under metabolic stress to regulate energy homeostasis. Upon activation, AMPK phosphorylates and inactivates key enzymes such as acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), which are involved in fatty acid and cholesterol biosynthesis.
The beta 1 subunit may positively regulate AMPK activity and influence its localization through myristoylation and phosphorylation, acting as an adaptor molecule within the AMPK complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.