Thermo Fisher Scientific HVCN1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human HVCN1. Recombinant protein control fragment (Product #RP-91100). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HVCN1,uniProtId:Q96D96-1,ncbiNodeId:9606,antigenRange:215-273,antigenLength:273,antigenImageFileName:PA5-58737_HVCN1_Q96D96-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58737_HVCN1_Q96D96-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642591

Product Specific Information

Immunogen sequence: GIIISVKTRS ERQLLRLKQM NVQLAAKIQH LEFSCSEKEQ EIERLNKLLR QHGLLGEVN

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 86%.

Target Information

HVCN1 (hydrogen voltage-gated channel 1), a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 may represent a new therapeutic target for B cell malignancies on continued signaling via the B cell antigen receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.