Thermo Fisher Scientific HVCN1 Polyclonal Antibody
Rabbit polyclonal antibody against human HVCN1. Tested for IHC (Paraffin) applications. High specificity with recombinant protein immunogen. Suitable for research use only. Stable storage at -20°C with glycerol buffer.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HVCN1. Recombinant protein control fragment (Product # RP-91100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642591 |
Product Specific Information
Immunogen sequence:
GIIISVKTRS ERQLLRLKQM NVQLAAKIQH LEFSCSEKEQ EIERLNKLLR QHGLLGEVN
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 86%
Target Information
HVCN1 (hydrogen voltage-gated channel 1) is a voltage-gated proton channel protein highly expressed in immune tissues. It mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance with their electrochemical gradient. It is sensitive to zinc ions and can be inhibited by them. HVCN1 may represent a potential therapeutic target for B cell malignancies through continued signaling via the B cell antigen receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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