Thermo Fisher Scientific MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Monoclonal Antibody (2F6)
MAP3K1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot 및 IHC 분석에 적합합니다. 인간 시료 반응성이 있으며, Protein A/G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific MAP3K1 Monoclonal Antibody (Clone 2F6)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F6 |
| Immunogen | Partial recombinant MAP3K1 (aa1077–1176) sequence: SKNSMTLDLN SSSKCDDSFG CSSNSSNAVI PSDETVFTPV EEKCRLDVNT ELNSSIEDLL EASMPSSDTT VTFKSEVAVL SPEKAENDDT YKDDVNHNQK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK (ERK), MAPK kinase (MEK), and MAPK kinase kinase (MEKK). MAPKKK/MEKK phosphorylates and activates MAPKK/MEK, which in turn activates MAPK. These kinases are highly conserved across species such as yeast, Drosophila, and mammals.
MEKK1 phosphorylates and activates MAPKK1 and MAPKK2 (MEK1/MEK2), leading to MAP kinase activation and efficient stimulation of the JNK cascade. The protein contains one RING-type zinc finger and one SWIM-type zinc finger.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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