Thermo Fisher Scientific LRP6 Polyclonal Antibody
LRP6 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체. Western blot, ICC/IF, ELISA에 사용 가능. 인간 및 생쥐 반응성, 친화 크로마토그래피로 정제. Wnt/β-catenin 신호전달 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–150 of human LRP6 (NP_002327.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.14 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805395 |
Product Specific Information
Immunogen sequence:
APLLLYANRR DLRLVDATNG KENATIVVGG LEDAAAVDFV FSHGLIYWSD VSEEAIKRTE FNKTESVQNV VVSGLLSPDG LACDWLGEKL YWTDSETNRI EVSNLDGSLR KVLFWQELDQ PRAIALDPSS G
Positive Samples: Mouse liver
Cellular Location: Endoplasmic reticulum, Membrane, Single-pass type I membrane protein
Target Information
LRP6 is essential for the Wnt/β-catenin signaling pathway, acting as a coreceptor with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. Interaction with DKK1 blocks LRP6-mediated Wnt/β-catenin signaling via LRP6 removal through Kremen protein-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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