Thermo Fisher Scientific MTH1 Polyclonal Antibody
Human MTH1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ELISA, Immunoprecipitation에 적합합니다. 고순도 Affinity Chromatography 정제 및 PBS/glycerol buffer로 안정화되어 있습니다. 산화 손상 DNA 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–179 of human MTH1 (NP_945192.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.94 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805396 |
Product Specific Information
Immunogen sequence:
MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC TDSIQGTPVE SDEMRPCWFQ LDQIPFKDMW PDDSYWFPLL LQKKKFHGYF KFQGQDTILD YTLREVDTV
Positive Samples: SW480, K562, 22RV1, THP-1, HepG2, SKOV3, 293T
Cellular Location: Cytoplasm, Mitochondrion matrix, Nucleus
Target Information
Oxygen radicals damage chromosomal DNA, causing cell death and inducing mutations. Among the various classes of DNA damage caused by oxygen radicals, an oxidized form of guanine base (8-oxoguanine) is important as it can pair with cytosine and adenine, leading to G:C to T:A transversion mutations.
A significant amount of 8-OxoG is formed in mammalian DNA, with most damaged nucleotides excised and excreted in urine. Additionally, 8-oxo-deoxyguanosine (8-oxo-dGTP) is formed in the nucleotide pool during normal metabolism and oxidative stress. This oxidized nucleotide can be misincorporated into DNA unless repaired.
MTH1 converts 8-oxo-dGTP to its monophosphate form, preventing misincorporation into DNA. It also recognizes 8-oxo-rGTP, which can otherwise lead to erroneous RNA transcription and abnormal protein production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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