Thermo Fisher Scientific JIP1 Polyclonal Antibody
JIP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적용 가능. 고순도 Protein A 및 항원 친화 크로마토그래피 정제. 인간 시료 반응성. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 470–498 from the C-terminal region of human JIP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543530 |
Target Information
The protein encoded by this gene regulates pancreatic beta-cell function and is highly similar to mouse JIP-1, a regulator of c-Jun N-terminal kinase (MAPK8). It inhibits MAPK8-mediated activation of transcription factors and reduces IL-1β and MEKK1-induced apoptosis in pancreatic beta cells. Additionally, it functions as a DNA-binding transactivator of the glucose transporter GLUT2. REST is known to repress expression of this gene in insulin-secreting beta cells. Mutations have been associated with type 2 diabetes susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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