Thermo Fisher Scientific CD34 Monoclonal Antibody (QBEND/10), PE
CD34 단백질을 인식하는 QBEND/10 클론의 단클론 항체로, PE 형광 표지되어 있습니다. 인간 및 비인간 영장류 시료에 반응하며, Flow Cytometry, IHC, ICC/IF에 적합합니다. 혈액 줄기세포 및 내피세포 표지 연구에 유용합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 94 publications |
| Immunocytochemistry (ICC/IF) | - | View 3 publications |
| Flow Cytometry (Flow) | 20 µL / 1x10^6 cells | View 7 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human, Mouse, Rabbit, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | QBEND/10 |
| Immunogen | Human endothelial vesicles |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152571 |
Additional Formats:
Product Specific Information
This antibody reacts with an extracellular class II epitope on CD34, a 110–115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitor cells and pluripotential stem cells. It is gradually lost on progenitor cells and can also be used as an endothelial marker.
Target Information
CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on various stem cell populations. It functions as a stem cell marker and may act as a receptor involved in adhesion, differentiation, and proliferation of hematopoietic stem cells. CD34 expression represents a specific developmental state of hematopoietic cells with distinct adhesion properties. It may mediate attachment of stem cells to bone marrow extracellular matrix or stromal cells and serve as a scaffold for lineage-specific glycans. The intracellular domain is phosphorylated by protein kinase C, suggesting a role in signal transduction. CD34 dysfunction is associated with diseases such as dermatofibrosarcoma and neurofibroma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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