Thermo Fisher Scientific CD4 Recombinant Rat Monoclonal Antibody (YNB46.1.8 (Campath-9H))
CD4 인간 항원을 인식하는 랫트 유래 재조합 단클론 항체로, WB, IHC, Flow Cytometry 등 다양한 실험에 적합. HEK293 발현 시스템에서 생산되었으며, Protein A로 정제된 고순도 항체. 인간 CD4에 특이적으로 결합하며 면역학 및 HIV 연구에 활용 가능.
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Thermo Fisher Scientific CD4 Recombinant Rat Monoclonal Antibody (YNB46.1.8 (Campath-9H))
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | YNB46.1.8 (Campath-9H) |
| Immunogen | Rat T-cell line (NB2) transfected with the human CD4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074258 |
Product Specific Information
Specificity: Recognizes the 55kDa human CD4 cell surface antigen, expressed by helper T lymphocytes and by monocytes.
Target Information
The CD4 antigen is involved in the recognition of MHC class II molecules and acts as a co-receptor for HIV. CD4 is primarily expressed in T helper lymphocytes, but may also be found in monocytes, macrophages, and dendritic cells. Tissue-level expression includes thymus, lymph nodes, tonsils, spleen, and certain regions of the brain and gut. CD4 functions to initiate or augment early T-cell activation via association with the T-cell receptor complex and Lck protein tyrosine kinase. It may also play a role in neuronal damage during infectious or immune-mediated CNS diseases. Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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