Thermo Fisher Scientific SLC28A1 Polyclonal Antibody
Human SLC28A1 단백질에 특이적인 Rabbit Polyclonal Antibody로 IHC(P) 등 연구용에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 저장. 4°C 단기, -20°C 장기 보관 권장.
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC28A1. Recombinant protein control fragment (Product # RP-90997) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647435 |
Product Specific Information
Immunogen sequence:
MENDPSRRRE SISLTPVAKG LENMGADFLE SLEEGQLPRS DLSPAEIRSS WSEAAPKPFS RWRNLQPA
Highest antigen sequence identity to the following orthologs:
- Mouse: 65%
- Rat: 59%
Target Information
Nucleosides play a role in signaling in several physiologic systems, and synthetic analogs of natural nucleosides are often used to treat neoplastic and viral diseases. Plasma membrane transport of nucleosides is mediated by equilibrative and concentrative nucleoside transporters, which may have specificity for purines or pyrimidines.
The deduced human 650 amino acid concentrative nucleoside transporter 1 (CNT1) protein is 83% identical to the rat protein and is expressed in the intestine, kidney, and liver. CNT1, also designated solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (SLC28A1), expedites sodium-dependent fluxes of uridine, azidodeoxythymidine (AZT), and adenosine, but not of guanosine or deoxyadenosine, which undergo net renal secretion. CNT1 activity may serve as a putative mechanism for renal reabsorption of physiologic nucleosides and synthetic nucleoside drugs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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