Thermo Fisher Scientific MCP-2 Recombinant Rabbit Monoclonal Antibody (3H18L3)

Applications

Western Blot (WB)

• Tested Dilution: 2–3 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:20

Product Specifications

Product Specific Information

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generates a ~25 kDa light chain band and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

Target Information

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes.

The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily characterized by two adjacent cysteine residues.

This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils, and eosinophils. By recruiting leukocytes to sites of inflammation, this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.