Thermo Fisher Scientific MIP-1 beta Polyclonal Antibody
Thermo Fisher Scientific의 MIP-1 beta Polyclonal Antibody는 돼지 CCL4 단백질에 특이적인 항체로, Western blot, ELISA, IP 등 다양한 응용에 적합합니다. Protein A로 정제된 액상 항체로 높은 순도와 안정성을 제공하며, 장기 보관 시 -20°C 이하에서 안정적입니다.
- 카탈로그번호
- 214-401-B85x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MIP-1 beta Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| ELISA (ELISA) | >1:5,000 |
| Immunoprecipitation (IP) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein raised in yeast, corresponding to the 69 amino acids of the mature swine CCL4/MIP1beta protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at 4°C prior to restoration. For extended storage, aliquot contents and freeze at -20°C or below.
- Avoid freeze/thaw cycles. Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
- This antibody is specific for swine CCL4 protein.
- BLAST analysis suggests cross-reactivity with horse and panda CCL4 (90% homology).
- Cross-reactivity with other species has not been determined.
- Swine CCL4 sequence shows 86% homology to swine CCL3L1.
Target Information
CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the chemokine CC family.
It plays roles in chemotactic and proinflammatory responses, produced by macrophages upon endotoxin stimulation.
CCL4 recruits and activates inflammatory cells such as lymphocytes, macrophages, and dendritic cells.
Both CCL4 and CCL3 regulate immune responses to bacterial, viral, parasitic, and fungal pathogens.
CCL4 selectively attracts CD4+ lymphocytes, while CCL3 attracts CD8+ lymphocytes.
Both act as potent chemoattractants for B cells, eosinophils, and dendritic cells.
Processed CCL4 can down-modulate CCR5 receptor expression, inhibiting CCR5-mediated HIV-1 entry in T cells.
CCL4 binds with high affinity to CCR5 receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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