Thermo Fisher Scientific CD80 (B7-1) Recombinant Rat Monoclonal Antibody (RM80)
Thermo Fisher Scientific의 CD80 (B7-1) Recombinant Rat Monoclonal Antibody (RM80)은 마우스 CD80 단백질에 특이적인 항체로 다양한 응용 실험(WB, IHC, Flow 등)에 사용 가능. HEK293 세포에서 발현된 recombinant monoclonal 형태로 높은 순도와 안정성을 제공. 연구용으로만 사용.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- Flow Cytometry (Flow): Assay-dependent
- Functional Assay (Functional): Assay-dependent
- Inhibition Assays (IA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RM80 |
| Immunogen | This antibody was raised by immunising Sprague Dawley rats with a mouse B cell line, BCL1 and fusing immune splenocytes with P3U1 myeloma cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074576 |
Product Specific Information
Specificity: This antibody is specific for murine CD80, a ~55 kDa member of the Ig superfamily.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of the T cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both are expressed on professional antigen-presenting cells and are essential for T cell activation. CD80 is rapidly induced on activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes through binding to CD28 and CTLA4. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-48133_CD80_B7-1_Q00609-1_Rat.svg, MA5-48133_CD80_B7-1_Q00609-1_Rat_PDP.jpeg)
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