Thermo Fisher Scientific HOXA11 Monoclonal Antibody (8B8)
HOXA11 단백질을 인식하는 마우스 단클론 항체로 Western blot 및 ELISA에 적합합니다. 인체 시료에 반응하며, 정제된 액상 형태로 제공됩니다. PBS(pH 7.4) 버퍼에 보존되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8B8 |
| Immunogen | HOXA11 (NP_005514, 60 a.a. approximately 166 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
VTFREYAIEP ATKWHPRGNL AHCYSAEELV HRDCLQAPSA AGVPGDVLAK SSANVYHHPT PAVSSNFYST VGRNGVLPQA FDQFFETAYG TPENLASSDY PGDKSAE
Target Information
HOX11, also called homeobox11 or Tcl-3, is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, with a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11 protein binds to specific DNA sequences and localizes to the cell nucleus, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of t(7:10)(q35;q24) or t(10:14)(q24;q11) translocations. Deregulation of the homeobox gene upon translocation into the T-cell receptor locus activates a subset of tumor-associated target genes. HOX11 gene translocation has been associated with T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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