Thermo Fisher Scientific HOXA11 Monoclonal Antibody (7E12)
HOXA11 단백질을 인식하는 Mouse monoclonal antibody (Clone 7E12). Western blot과 ELISA에 적합하며, Human 시료 반응성. Affinity chromatography로 정제된 액상 항체로, PBS(pH 7.4)에 보존제 없이 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7E12 |
| Immunogen | HOXA11 (NP_005514, 60 a.a. approximately 166 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
VTFREYAIEP ATKWHPRGNL AHCYSAEELV HRDCLQAPSA AGVPGDVLAK SSANVYHHPT PAVSSNFYST VGRNGVLPQA FDQFFETAYG TPENLASSDY PGDKSAE
Target Information
HOX11 (also known as HOXA11 or Tcl-3) is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain containing protein with a glycine- and proline-rich amino terminus. HOX11 is essential for spleen development and cell survival, binding specific DNA sequences and localizing to the nucleus. It functions as a transcription activator of target genes. HOX11 is highly expressed in T-ALLs due to chromosomal translocations such as t(7;10)(q35;q24) or t(10;14)(q24;q11), which deregulate its expression and contribute to T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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