Thermo Fisher Scientific Lamin A/C (R453W) Monoclonal Antibody (12A-2F5)
인간 Lamin A/C (R453W) 변이체를 인식하는 단클론 항체로, WB, ICC/IF, IP에 사용 가능. 1 mg/mL 농도의 액상형 항체이며 Protein G로 정제됨. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:8,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 12A-2F5 |
| Immunogen | KLH-coupled peptide from human Lamin A/C (Immunogen Sequence: 449-GKFVWLRNK-457) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539441 |
Product Specific Information
This antibody recognizes the EDMD-associated lamin A/C mutant strain R453W.
The target has a predicted molecular weight of 65 kDa.
Target Information
Lamins are intermediate filament proteins forming a matrix on the inner surface of the nuclear envelope. They exist in three forms (A, B, and C) and are found in various cell types. Lamins A and C are splice variants of the LMNA gene, which is associated with multiple disorders such as Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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