Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI6F5), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules. Platelet factor XIII consists only of two A subunits identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme, factor XIIIa, identical to platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules, stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency (lack of both A and B subunits) and type II deficiency (lack of A subunit alone). These defects can result in lifelong bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.