Thermo Fisher Scientific CCL3L1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Store vial at 4°C prior to restoration. For extended storage, aliquot contents and freeze at -20°C or below. Avoid freeze/thaw cycles. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

This antibody is specific for swine CCL3L1 protein. A BLAST analysis suggests cross-reactivity with CCL3L1 from bovine sources based on 100% homology with the immunizing sequence. Partial reactivity is expected against CCL3L1 from cat, dog, human, chimpanzee, baboon, bovine, and rat based on greater than 90% sequence homology. Cross-reactivity with CCL3L1 from other sources has not been determined.

Target Information

This gene is part of a cytokine gene cluster on the q-arm of chromosome 17. Cytokines are secreted proteins involved in inflammatory and immunoregulatory processes. The encoded protein binds to several chemokine receptors, including CCR5, which serves as a co-receptor for HIV. Binding of this protein to CCR5 inhibits HIV entry. The gene copy number varies among individuals, with most having one to six copies. There are conflicting reports regarding copy number variation and disease susceptibility. This record represents one of two copies present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.