ELK Biotechnology V-ATPase D rabbit pAb

ELK Biotechnology V-ATPase D rabbit pAb

제품 개요

V-ATPase D rabbit polyclonal antibody는 진핵세포 내 소기관의 산성화를 매개하는 V-ATPase 복합체의 D 서브유닛을 인식합니다. 단백질 분류, 효소 활성화, 수용체 매개 내포작용 등 다양한 세포 내 과정 연구에 활용됩니다.

제품 정보

세포 내 위치

Membrane; Peripheral membrane protein; Cytoplasmic side.
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Cell projection, cilium.
Localizes to centrosome and the base of the cilium.

Background

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase-dependent organelle acidification is necessary for intracellular processes such as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.
V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits, and contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c’, c”, and d. Additional isoforms of many V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. (provided by RefSeq, Jul 2008)