ELK Biotechnology Septin 2 rabbit pAb

제품명

Septin 2 rabbit pAb

기본 정보

세포 내 위치

Cytoplasm, cytoskeleton, spindle, chromosome centromere, kinetochore, cleavage furrow, midbody, cell cortex, cilium membrane, flagellum.
In metaphase cells, localized within the microtubule spindle and near the kinetochores of congressed chromosomes.
During cytokinesis, localized to the midbody, ingressing cleavage furrow, and central spindle.
In bacterial infection, forms a collar-shaped structure adjacent to actin at the pole of invading bacteria.
In epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network and proximal Golgi apparatus.
Localizes at the base of the cilium.

배경 정보

• Function: Required for normal progress through mitosis and involved in cytokinesis.
• Similarity: Belongs to the septin family.
• Subcellular location: Accumulates near the contractile ring from anaphase through telophase, condensing into the midbody. In interphase and postmitotic cells, localizes to fibrous or granular structures depending on cell growth state.
• Subunit: Monomer and homodimer forms. Nucleotide binding promotes dimerization. Forms heterohexamers composed of two heterotrimers (SEPT2, SEPT6, SEPT7) that assemble into filaments.

보관 및 안정성

• Host: Rabbit
• Storage Condition: -20°C, 1년 안정성 유지

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