ELK Biotechnology Met (phospho Tyr1003) rabbit pAb

제품명

Met (phospho Tyr1003) rabbit pAb

공급업체

ELK Biotechnology

제품 개요

이 항체는 인간 c-Met 단백질의 Tyr1003 인산화 부위를 인식하도록 제작된 rabbit polyclonal antibody입니다. 다양한 면역 분석 응용(WB, IHC, IF, ELISA)에 적합하며, 세포막 단백질 연구에 활용됩니다.

제품 사양

Background

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. (provided by RefSeq, May 2016)