ELK Biotechnology MRE11 (phospho Ser264) rabbit pAb
MRE11 단백질의 Ser264 인산화 부위를 인식하는 토끼 폴리클로날 항체로, WB, ELISA, IHC에 사용 가능. 인간, 마우스, 랫트 반응성. 핵 및 염색체 부위에서 DNA 이중가닥 절단 복구 연구에 적합. -20°C에서 1년 보관.
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MRE11 (phospho Ser264) rabbit pAb
제품 개요
ELK Biotechnology의 MRE11 (phospho Ser264) rabbit polyclonal antibody는 인간 MRE11 단백질의 Ser264 인산화 부위를 인식하도록 제작된 항체입니다. DNA 손상 복구, 염색체 안정성, 텔로미어 유지 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MRE11 (phospho Ser264) rabbit pAb |
| Alternative Names | MRE11A; HNGS1; MRE11; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–1:20000 |
| Immunogen | Synthesized peptide derived from human MRE11 around the phosphorylation site of Ser264 (AA range: 230–279) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kDa |
| Gene ID (Human) | 4361 |
| Human Swiss-Prot No. | P49959 |
| Cellular Localization | Nucleus; Chromosome; Telomere. Localizes to discrete nuclear foci after treatment with genotoxic agents. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. The protein exhibits 3′ to 5′ exonuclease and endonuclease activity and forms a complex with the RAD50 homolog, which is essential for nonhomologous DNA end joining. This complex enhances single-stranded DNA endonuclease and exonuclease activities. Together with DNA ligase, it facilitates the joining of noncomplementary DNA ends in vitro using short homologies near the DNA fragment termini. A pseudogene exists on chromosome 3, and alternative splicing results in two transcript variants encoding different isoforms. (RefSeq, Jul 2008)
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