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ELK Biotechnology MDM2 (phospho Ser186/S188) rabbit pAb
상품 한눈에 보기
MDM2 단백질의 Ser186/Ser188 인산화 부위를 인식하는 Rabbit Polyclonal 항체. WB, IF, ELISA에 적합하며 핵 및 세포질에서 발현되는 MDM2 검출에 유용. p53 관련 종양 연구에 활용 가능. -20°C에서 1년 보관.
- 판매단위
- pk
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ELK Biotechnology ES6210-100UL MDM2 (phospho Ser186/S188) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES6210-50UL MDM2 (phospho Ser186/S188) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology MDM2 (phospho Ser186/S188) rabbit pAb
제품명
MDM2 (phospho Ser186/S188) rabbit pAb
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2 |
| Applications | IF; WB; ELISA |
| Recommended Dilutions | WB: 1:500–2000 Immunofluorescence: 1:200–1:1000 ELISA: 1:20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human MDM2 around the phosphorylation site of Ser186 and Ser188 (AA range: 151–200) |
| Storage | −20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4193 |
| Human Swiss-Prot No | Q00987 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Nucleus, nucleoplasm, cytoplasm, nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in localization of both proteins to the nucleolus. Colocalizes with RASSF1 isoform A in the nucleus. |
| Background | This gene encodes a nuclear-localized E3 ubiquitin ligase that promotes tumor formation by targeting tumor suppressor proteins such as p53 for proteasomal degradation. It is transcriptionally regulated by p53, and overexpression or amplification is observed in various cancers. A pseudogene exists on chromosome 2. Alternative splicing produces multiple transcript variants, many expressed only in tumor cells. (RefSeq, Jun 2013) |
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