ELK Biotechnology Smad4 rabbit pAb
Smad4 rabbit pAb는 인간 Smad4 단백질을 인식하는 고품질 폴리클로날 항체입니다. WB, IHC, IF, ELISA 등 다양한 응용에 적합하며, 세포 내 위치 연구에 활용 가능합니다. 인간, 마우스, 랫, 원숭이에 반응하며 -20°C에서 1년간 안정적으로 보관됩니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Smad4 rabbit pAb
ELK Biotechnology Smad4 rabbit pAb
제품 개요
Smad4 rabbit pAb는 인간 Smad4 단백질을 타겟으로 제작된 폴리클로날 항체로, TGF-beta 신호전달 경로 연구에 적합합니다. 다양한 면역학적 응용(WB, IHC, IF, ELISA)에 사용 가능합니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | Smad4 rabbit pAb |
| Alternative Names | SMAD4; DPC4; MADH4; Mothers against decapentaplegic homolog 4; MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Smad4 (AA range: 21–70) |
| Species Reactivity | Human; Mouse; Rat; Monkey |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 4089 |
| Human Swiss-Prot No | Q13485 |
| Cellular Localization | Cytoplasm and nucleus. Cytoplasmic in the absence of ligand; migrates to the nucleus when complexed with R-SMAD (PubMed:15799969). PDPK1 prevents nuclear translocation in response to TGF-beta (PubMed:17327236). |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric and heteromeric complexes with other activated Smad proteins, which accumulate in the nucleus to regulate transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). Mutations or deletions in this gene are associated with pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [RefSeq, Oct 2009]
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.