ELK Biotechnology Smad2 rabbit pAb
Smad2 rabbit polyclonal antibody로 TGF-β 신호 전달 관련 단백질 검출에 사용. WB, IHC, IF, ELISA 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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제품명
Smad2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2 |
| Applications | WB; CoIP; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Smad2 (AA range: 418-467) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 58 kD |
| GeneID (Human) | 4087 |
| Human Swiss-Prot No | Q15796 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm and nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex and exported out of the nucleus by interaction with RANBP1. Localized mainly to the nucleus in early embryo development, later evident in cytoplasm at blastocyst and epiblast stages.
배경 정보
The protein encoded by this gene belongs to the SMAD family, which are signal transducers and transcriptional modulators mediating multiple signaling pathways. Smad2 mediates the signal of transforming growth factor (TGF)-β, regulating cellular processes such as proliferation, apoptosis, and differentiation. It is recruited to TGF-β receptors via interaction with SARA protein. Upon TGF-β stimulation, Smad2 is phosphorylated, dissociates from SARA, and associates with SMAD4—an essential step for nuclear translocation and transcriptional regulation.
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