ELK Biotechnology Rho G rabbit pAb
Rho G rabbit polyclonal antibody for WB, IHC, IF, ELISA applications. Recognizes human RHOG protein involved in cytoskeleton reorganization and cell motility. High specificity and stability with long-term storage at -20°C. Suitable for human, mouse, an...
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Rho G rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RHOG; ARHG; Rho-related GTP-binding protein RhoG |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human RHOG (AA range: 97–146) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 23 kD |
| GeneID (Human) | 391 |
| Human Swiss-Prot No | P84095 |
| Cellular Localization | Cell membrane; Lipid-anchor; Cytoplasmic side |
| Species Reactivity | Human; Mouse; Rat |
배경 (Background)
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades.
Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility.
The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane, where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration.
Two related pseudogenes have been identified on chromosomes 20 and X. (RefSeq, Aug 2011)
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