Thermo Fisher Scientific Phospho-c-ABL (Thr394) Polyclonal Antibody
Phospho-c-ABL (Thr394) 항체로 인간, 마우스, 랫트 시료에 반응합니다. IHC, ICC/IF, Flow, ELISA 등 다양한 응용에 사용 가능하며, Protein A로 정제된 Rabbit Polyclonal Antibody입니다. -20°C에서 보관하며, 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human c-Abl isoform b around the phosphorylation site of Thr394 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response. The c-Abl protein’s activity is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene. Its DNA-binding activity is regulated by CDC2-mediated phosphorylation, linking it to cell cycle control. In chronic myelogenous leukemia and some acute lymphoblastic leukemias, a (9;22) chromosomal translocation produces the Philadelphia chromosome, fusing c-Abl sequences from chromosome 9 with the Bcr gene on chromosome 22. The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-ABL also plays a role in DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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