Thermo Fisher Scientific Phospho-c-ABL (Tyr204) Polyclonal Antibody
Phospho-c-ABL (Tyr204) 폴리클로날 항체로 인간, 생쥐, 랫트 시료에 반응하며 다양한 응용 실험(WB, IHC, ICC, ELISA)에 사용 가능. Protein A로 정제된 고순도 항체로, 세포 신호전달 및 암 관련 연구에 적합. -20°C 보관.
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Thermo Fisher Scientific Phospho-c-ABL (Tyr204) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human c-Abl isoform b around the phosphorylation site of Tyr204 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response. Activity of c-Abl is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene. Its DNA-binding activity is regulated by CDC2-mediated phosphorylation, indicating a role in the cell cycle.
In chronic myelogenous leukemia and certain acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) translocation, forming the Philadelphia chromosome through fusion with the Bcr gene. The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-ABL may regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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