Thermo Fisher Scientific ARHGEF7 Polyclonal Antibody
ARHGEF7 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫에서 반응합니다. Western blot, ELISA, IP에 사용 가능하며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용됩니다.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 595–805 of human ARHGEF7 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The serine/threonine kinase, p21 activated kinase (PAK), acts as a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, PI3-kinase subunits (p85 and p110), and PIX (PAK-interacting exchange factor) in a focal complex. PIX binding is required for localization and activation of PAK in the Cdc42–Rac signaling pathway, mediated by the high affinity of the N-terminal SH3 domain of PIX for a conserved proline-rich PAK sequence.
PIX exists as two isoforms, alpha and beta, both highly expressed in heart, muscle, and thymus tissues of human and rat. AlphaPIX is phosphorylated via PDGF and EphB2 receptor signaling or through association with PI3-kinase. The alphaPIX isoform primarily functions as a guanine nucleotide exchange factor (GEF) for Rac, which may mediate lamellipodia formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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