Thermo Fisher Scientific Tubulin, beta Monoclonal Antibody (TUBB/4470)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance, and maintenance. Mutations in the beta tubulin gene are associated with congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin is also detected in Sertoli cells and transiently in non-neuronal embryonic tissues. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression, which inhibits tubulin incorporation into microtubules. Microtubules are essential cytoskeletal elements involved in chromosome segregation, intracellular transport, and structural support. Because beta-tubulin is ubiquitously expressed, it is frequently used as a loading control in protein detection assays such as Western blotting.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.