Thermo Fisher Scientific CD3 Monoclonal Antibody (OKT3)
인간 CD3 항원을 인식하는 OKT3 클론 단일클론 항체로, T세포 활성화 및 CD3 신호전달 연구에 적합. 다양한 응용(Flow, IHC, ICC 등)에 사용 가능하며, Protein A 정제, 1 mg/mL 농도의 액상 형태로 제공. 연구용으로만 사용.
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Thermo Fisher Scientific CD3 Monoclonal Antibody (OKT3)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | 1 publication |
| Immunocytochemistry (ICC/IF) | Assay-dependent | 1 publication |
| Flow Cytometry (Flow) | 1 µg/mL | 2 publications |
| T-Cell Activation (TCA) | - | 1 publication |
| In vitro Assay (IV) | - | 1 publication |
| Miscellaneous PubMed (Misc) | - | 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OKT3 |
| Immunogen | Human T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157849 |
Product Specific Information
This antibody recognizes an extracellular epitope on the CD3 antigen of the TCR/CD3 complex on mature human T cells. Also known as Orthoclone OKT3 or Muromonab-CD3, it has been used therapeutically for acute, glucocorticoid-resistant rejection of allogenic renal, heart, and liver transplants. It has also been investigated for treatment of T-cell acute lymphoblastic leukemia.
Target Information
The CD3 subunit complex is crucial for transducing antigen-recognition signals into T-cell cytoplasm and regulating TCR complex expression. Activation through the TCR involves CD3 gamma, delta, epsilon, and zeta subunits, which are structurally related members of the immunoglobulin superfamily encoded on human chromosome 11. CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation. CD3 antigen is present on 68–82% of peripheral blood lymphocytes and 65–85% of thymocytes, but not on B or NK cells. Defects in CD3 genes are associated with CD3 immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- MA1-10175_CD3_P07766-1_House_mouse.svg
- MA1-10175_CD3_P04234-1_House_mouse.svg
- MA1-10175_CD3_P09693-1_House_mouse.svg
- MA1-10175_CD3_P20963-1_House_mouse.svg
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