Thermo Fisher Scientific NOTCH2 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal 항체. Western blot, ICC/IF, ELISA에 사용 가능. Affinity Chromatography로 정제된 액상 항체로, PBS/glycerol buffer에 보관. 세포막, 세포질, 핵에서 NOTCH2 단백질 검출에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 2242–2471 of human NOTCH2 (NP_0777192) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.16 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804163 |
Product Specific Information
Immunogen sequence:
SRLHPVPVPA DWMNRMEVNE TQYNEMFGMV LAPAEGTHPG IAPQSRPPEG KHITTPREPL PPIVTFQLIP KGSIAQPAGA PQPQSTCPPA VAGPLPTMYQ IPEMARLPSV AFPTAMMPQQ DGQVAQTILP AYHPFPASVG KYPTPPSQHS YASSNAAERT PSHSGHLQGE HPYLTPSPES PDQWSSSSPH SASDWSDVTT SPTPGGAGGG QRGPGTHMSE PPHNNMQVYA
Positive Samples: 293T, LO2, HeLa
Cellular Location: Cell membrane, Cytoplasm, Nucleus, Single-pass type I membrane protein
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved protein in the Notch signaling pathway. It is a type I transmembrane receptor with multiple epidermal growth factor-like (EGF) repeats in the extracellular domain and various domains in the intracellular region. NOTCH2 interacts with ligands such as Jagged1, Jagged2, and Delta1 to regulate cell fate determination.
Defects in NOTCH2 cause Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity, cholestasis, and associated cardiac, skeletal, and ophthalmologic manifestations, sometimes involving renal and vascular systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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