Thermo Fisher Scientific SLA Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 5–15 µg/mL

Product Specifications

Target Information

SLAP (Src-like-adapter protein 1) is a 276-amino-acid adapter protein functioning as a negative regulator of T-cell receptor (TCR) signaling. It belongs to the SRC family of cytoplasmic tyrosine kinases and contains SH2 and SH3 domains. This cytoplasmic protein colocalizes with endosomes and inhibits T-cell antigen receptor-induced activation of nuclear factor of activated T-cells. SLAP negatively regulates positive selection and mitosis of T-cells by linking signaling proteins such as ZAP70 with CBL, leading to CBL-dependent degradation of signaling proteins. Expression is weak in heart, adult brain, placenta, liver, skeletal muscle, kidney, and pancreas, but high in lung and fetal brain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.