Thermo Fisher Scientific SLA Polyclonal Antibody
Rabbit polyclonal antibody targeting SLAP protein for IHC (Paraffin) applications. Recognizes synthetic peptide aa193–210. Unconjugated liquid form, 0.5 mg/mL concentration. Stored at -20°C, shipped on wet ice. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 5–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (TLRQKTVDWRRVSRLQED, aa193–210) of SLAP protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2540818 |
Target Information
SLAP (Src-like-adapter protein 1) is a 276-amino-acid adapter protein functioning as a negative regulator of T-cell receptor (TCR) signaling. It belongs to the SRC family of cytoplasmic tyrosine kinases and contains SH2 and SH3 domains. This cytoplasmic protein colocalizes with endosomes and inhibits T-cell antigen receptor-induced activation of nuclear factor of activated T-cells. SLAP negatively regulates positive selection and mitosis of T-cells by linking signaling proteins such as ZAP70 with CBL, leading to CBL-dependent degradation of signaling proteins. Expression is weak in heart, adult brain, placenta, liver, skeletal muscle, kidney, and pancreas, but high in lung and fetal brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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