Thermo Fisher Scientific CtIP Polyclonal Antibody
CtIP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 IHC에 적합하며 Human, Mouse, Rat 시료에서 반응. BRCA1 상호작용 연구 및 DNA 손상 반응 관련 연구에 유용. 항원 친화 크로마토그래피로 정제된 고품질 항체.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (IHC) | 5 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide near the center of human RBBP8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153016 |
Product Specific Information
- Suggested positive control: mouse spleen tissue lysate
- PA5-20963 can be used with blocking peptide PEP-1077
Target Information
CtIP, a 125 kDa protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein), suggesting a role in transcription regulation.
Studies have shown that CtIP also interacts with BRCA1 protein through the C-terminal BRCT domains, indicating that CtIP may act as a potential tumor suppressor.
This CtIP–BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma irradiation.
Li et al. (Nature 406, 210–215, 2000) demonstrated that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites prevents BRCA1 dissociation from CtIP, leading to persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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