Thermo Fisher Scientific PSMB8/LMP7 Polyclonal Antibody
인간 PSMB8/LMP7 단백질을 인식하는 토끼 폴리클로날 항체입니다. Western blot 및 면역침강(IP)에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 226 to 276 of Human Proteasome subunit beta type-8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure composed of four rings of 28 non-identical subunits (two rings of 7 alpha subunits and two rings of 7 beta subunits). Proteasomes are abundant in eukaryotic cells and function in an ATP/ubiquitin-dependent, non-lysosomal protein degradation pathway.
The immunoproteasome variant processes class I MHC peptides. The PSMB8 gene encodes a 20S core beta subunit, located in the MHC class II region, and its expression is induced by gamma interferon. This subunit replaces the proteasome beta 5 subunit in the immunoproteasome. Proteolytic processing generates the mature subunit. Two alternative transcripts produce isoforms that yield the same mature protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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