Thermo Fisher Scientific LKB1 Polyclonal Antibody
LKB1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, Flow Cytometry에 사용 가능. 인간 시료에 반응하며, 예측상 닭, 생쥐, 랫트에도 반응. 1 mg/mL 농도의 액상 항체로, PBS buffer에 0.09% sodium azide 포함. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 19–48 of the N-terminal region of human STK11 (LKB1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term); for long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2271315 |
Product Specific Information
This antibody is predicted to react with chicken, mouse, and rat based on sequence homology.
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11) is a tumor suppressor belonging to the serine/threonine kinase family. It associates with p53 and regulates p53-dependent apoptosis pathways. LKB1 is localized in both cytoplasm and nucleus and translocates to mitochondria during apoptosis. It acts as a master upstream kinase regulating AMPK and related kinases. Mutations in the LKB1 gene are linked to Peutz-Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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