Thermo Fisher Scientific LKB1 Polyclonal Antibody
Thermo Fisher Scientific의 LKB1 Polyclonal Antibody는 인간 LKB1 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot, IHC, ICC/IF, Flow cytometry에 적합하며, 고순도 액상 형태로 제공됩니다. 세포 내 LKB1 연구 및 암 관련 신호전달 분석에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 14–44 amino acids from the N-terminal region of human STK11 (LKB1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at –20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2286883 |
Product Specific Information
This antibody is predicted to react with chicken, mouse, rat, and Xenopus based on sequence homology.
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11) is a tumor suppressor and a member of the serine/threonine kinase family. It associates with p53 and regulates p53-dependent apoptosis pathways. LKB1 is localized in both cytoplasm and nucleus, and translocates to mitochondria during apoptosis. It acts as a master upstream kinase regulating AMPK-related kinases and AMPK itself. Mutations in the LKB1 gene are associated with Peutz-Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-14072_LKB1_Q15831-1_Rabbit.svg, PA5-14072_LKB1_Q15831-1_Rabbit_PDP.jpeg)
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